Five hundred years ago, a group of Spanish conquistadors land in the New World, searching for gold. What they find is a treasure far more valuable: the Fountain of Youth. The Spaniards slaughter the Native American tribe that guards the precious liquid that will keep the conquistadors young for centuries. But one of them escapes: Shako, the chief's daughter, who swears to avenge her people--a blood oath that spans five centuries. When the source of the fountain is destroyed in our own time, the loss threatens the Spaniards and the powerful, shadowy empire of wealth and influence they have built. For help, they turn to David Robinton, a scientific prodigy who believes he is on the verge of the greatest medical breakthrough of all time. But as the centuries-old war reaches its final stages, David makes a horrifying discovery about his employers and the mysterious and exotic woman he loves. Now the scientist must decide: Is he a pawn in a game of immortals--or will he be its only winner?