Twenty years ago, aliens from another planet made contact with Earth. Now, the refugee camp they are forced to live in has deteriorated into a slum-like ghetto. When field operative Wikus van der Merwe is put in charge of evicting the aliens, he contracts a strange virus that changes his DNA to match that of the refugees. As his body begins to mutate, he becomes a hunted man, and the aliens' only hope for freedom.

Twenty years ago, aliens from another planet made contact with Earth. Now, the refugee camp they are forced to live in has deteriorated into a slum-like ghetto. When field operative Wikus van der Merwe is put in charge of evicting the aliens, he contracts a strange virus that changes his DNA to match that of the refugees. As his body begins to mutate, he becomes a hunted man, and the aliens' only hope for freedom.